Avevo già raccolto una serie di studi sull'argomento, mi sembra una correlazione molto interessante e ormai ben dimostrata. Raccogliamo qui un po' di studi?

More Evidence Links Cow’s Milk to Type 1 Diabetes

A new study adds more evidence that cow’s milk proteins trigger type 1 diabetes. Marcia Goldfarb of Anatek-EP, a protein research laboratory in Portland, Maine, reports having found antibodies to bovine beta-lactoglobulin in the serum of children with diabetes. Individuals without diabetes did not have the antibody.

Type 1 diabetes is believed to be caused when antibodies destroy the insulin-producing pancreatic cells. Several studies have suggested that cow’s milk proteins may trigger the production of these dangerous antibodies. Larger studies are currently testing this theory.

J Proteome Res. 2008 May;7(5):2165-7. Epub 2008 Apr 15.
Relation of time of introduction of cow milk protein to an infant and risk of type-1 diabetes mellitus. Goldfarb MF.

Several studies of infant feeding show a causal relationship between time of introduction of formula containing cow protein and risk of onset of type-1 diabetes mellitus. This paper cites the literature pro and con and discusses lipocalins which might play a role in the pathogensis. beta Lactoglobulin, a major lipocalin protein in bovine milk, is homologous to the human protein glycodelin (PP14), a T cell modulator. Anti-beta lactoglobulin cross-reacts with glycodelin. The newborn intestine does not have complete "closure" and can pass food antigens. beta Lactoglobulin could generate antibody to glycodelin undermining T cell regulation of beta cells.

Ecco gli studi che avevo segnalato in questi mesi su Pubmed. Ribo, una volta tu se no nerro avevi segnalato un modo di poter condividere un archivio di studi, puoi fare una mini guida cosi lo usiamo tutti? Non ricordo che sito era...

1.
Wahlberg J, Vaarala O, Ludvigsson J; ABIS-study group.
Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children.
Br J Nutr. 2006 Mar;95(3):603-8.
PMID: 16578935 [PubMed - indexed for MEDLINE]

2:
Birgisdottir BE, Hill JP, Thorsson AV, Thorsdottir I.
Lower consumption of cow milk protein A1 beta-casein at 2 years of age, rather than consumption among 11- to 14-year-old adolescents, may explain the lower incidence of type 1 diabetes in Iceland than in Scandinavia.
Ann Nutr Metab. 2006;50(3):177-83. Epub 2006 Jan 10.
PMID: 16407643 [PubMed - indexed for MEDLINE]

3:
Saukkonen T, Virtanen SM, Karppinen M, Reijonen H, Ilonen J, Räsänen L, Akerblom HK, Savilahti E.
Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype. Childhood Diabetes in Finland Study Group.
Diabetologia. 1998 Jan;41(1):72-8.
PMID: 9498633 [PubMed - indexed for MEDLINE]

4:
Virtanen SM, Saukkonen T, Savilahti E, Ylönen K, Räsänen L, Aro A, Knip M, Tuomilehto J, Akerblom HK.
Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children. Childhood Diabetes in Finland Study Group.
Diabetologia. 1994 Apr;37(4):381-7.
PMID: 8063039 [PubMed - indexed for MEDLINE]

5:
Saukkonen T, Savilahti E, Madácsy L, Arató A, Körner A, Barkai L, Sarnesto A, Akerblom HK.
Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus.
Eur J Pediatr. 1996 Oct;155(10):885-9.
PMID: 8891559 [PubMed - indexed for MEDLINE]

6:
Savilahti E, Saukkonen TT, Virtala ET, Tuomilehto J, Akerblom HK.
Increased levels of cow's milk and beta-lactoglobulin antibodies in young children with newly diagnosed IDDM. The Childhood Diabetes in Finland Study Group.
Diabetes Care. 1993 Jul;16(7):984-9.
PMID: 7993386 [PubMed - indexed for MEDLINE]

7:
Vaarala O.
Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin?
Adv Exp Med Biol. 2005;569:151-6. Review.
PMID: 16137120 [PubMed - indexed for MEDLINE]

Già in "Becoming Vegan" (2003) Vesanto Melina e Brenda Davis riportavano che - probabilmente - il problema non riguarda tanto il consumo totale di proteine dal latte, ma dipende dalle concentrazione di alcune proteine specifiche (beta-caseina A + B), che producono un peptide immuno-soppressivo (beta-casomofina-7), come suggerito da questo studio: http://www.ncbi.nlm.nih.gov/pubmed/10096780

Ma dando un'occhiata alle pubblicazioni successive mi sembra che anche al riguardo ci siano risultati contrastanti.

Physicians Committee for Responsible Medicine
Breaking Medical News

Avoiding Cow’s Milk May Cut Risk of Type 1 Diabetes

Children who are not exposed to cow's milk proteins during infancy may have less risk of developing type 1 diabetes, according to a new report in the American Journal of Clinical Nutrition. In the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR) study, women were encouraged to breastfeed. Those who then transitioned their infants to baby formula were given a specially prepared formula in which proteins were broken up so that no intact cow's milk proteins remained. The full study results are not yet in. However, the TRIGR pilot study, including 230 infants followed until about 10 years of age, showed that those who followed the special feeding plan were 60 percent less likely to develop type 1 diabetes, compared with children who drank regular cow's milk formula during infancy.

The study adds more support to the long-held theory that cow's milk proteins trigger the production of antibodies that can destroy a child's insulin-producing cells.

Knip M, Virtanen SM, Becker D, Dupré J, Krischer JP, Akerblom HK. Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR). Am J Clin Nutr. Published ahead of print Jun 8, 2011.

For information about nutrition and health, please visit http://www.pcrm.org/.

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www.pcrm.org/news/cows_milk_type_1_diabetes.html



Articolo in italiano a cura di SSNV:

Latte vaccino e diabete di tipo 1 | 23/07/2011

Il rischio di diabete di tipo 1 è minore nei bambini che non vengono nutriti con proteine di latte vaccino.

Secondo un nuovo studio pubblicato in giugno nell'American Journal of Clinical Nutrition, i bambini che non sono esposti alle proteine del latte vaccino durante l'infanzia possono avere un rischio minore di sviluppare il diabete di tipo 1. Questi risultati arrivano dal trial TRIGR - Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (Trial per ridurre il diabete mellito insulino-dipendente nelle persone geneticamente a rischio).

Durante lo studio, le donne che partecipavano venivano incoraggiate ad allattare al seno. A quelle che poi passavano ai latti formulati, veniva fornita una formula speciale in cui le proteine venivano modificate in modo che non rimanesse alcuna proteina intatta del latte di mucca.

I risultati finali sono ancora in corso di valutazione, tuttavia lo studio pilota, che comprende 230 bambini seguiti fino a circa 10 anni d'età, ha mostrato che coloro che erano stati nutriti con la formulazione speciale avevano il 50% di probabilità in meno di sviluppare il diabete di tipo 1, rispetto ai bambini che avevano consumato il normale latte formulato a base di latte vaccino.

Lo studio aggiunge quindi ulteriori evidenze alla teoria nota da tempo secondo cui le proteine del latte vaccino attiverebbero la produzione di anticorpi in grado di distruggere le cellule produttrici di insulina nei bambini.

Fonte:
Knip M, Virtanen SM, Becker D, Dupré J, Krischer JP, Akerblom HK. Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR). Am J Clin Nutr. Published ahead of print Jun 8, 2011.

www.scienzavegetariana.it/news_dett.php?id=1174